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Postdoc in Deep Mutational Scanning at the Department of Biology

We are looking for a highly motivated and independent Post Doc to lead a 2-year project focused on Deep Mutational Scanning applied to Intrinsically Disordered Proteins (IDPs) in yeast cells to commence 1 May 2027 or as soon as possible thereafter.

Our research

The research group investigates how cells maintain protein homeostasis through the protein quality control (PQC) system and how defects in these pathways contribute to disease and aging. Research activities combine molecular genetics, functional genomics, and advanced high-throughput technologies to dissect the mechanisms governing protein folding, degradation, and cellular stress responses.

A central focus is the development and application of Deep Mutational Scanning (DMS) approaches to systematically characterize the functional consequences of genetic variation in selected IDPs in yeast cells.



This will require developing and integrating multiplexed assays to uncover sequence–function relationships and map the cellular pathways that influence variant effects. This work provides fundamental insights into PQC and protein interaction networks and contributes to improved interpretation of human genetic variation in health and disease.

Your job

You will join a multidisciplinary research team investigating cellular protein quality control using advanced high-throughput technologies. Your work will include cloning large cDNA libraries, conducting genome-wide screens, and performing multiplexed assays to study the effects of genetic variants in yeast cells. The role requires close collaboration with researchers from diverse scientific backgrounds, integrating expertise from molecular biology, genetics, biophysics and computational biology.

Beyond your primary project, you will support ongoing research activities across the group on an ad hoc basis, contributing technical expertise, troubleshooting, and experimenta

📌 Postdoc in Deep Mutational Scanning at the Department of Biology (Asunción)
🏢 Department of Pharmacy, University of Copenhagen
📍 Asunción